I found collaborating with congenial doctors about problems that physicists could help solve was very satisfying. I also like educating anybody who would listen! ↗
I could do exploration in this particular career field, and it was a goal that, even if I didn't reach it, it was so high it seemed almost impossible, but even if I didn't reach it, I would still have a good time and a very satisfying career. ↗
So, for me, working with larger companies has often been very satisfying, precisely because of the ability of bringing critical mass to bear on a given effort. ↗