Our solution on 'The Simpsons' is to do jokes that people who have an education, or some frame of reference, can get. And for the ones who don't, it doesn't matter, because we have Homer banging his head and saying, 'D'oh!' ↗
I did a series called Ned and Stacey for two years for Fox back in the 90s. I was writer on it as well as a producer, and it was very important to me that there were no contemporary references. ↗
At the same time, new concepts and abstractions flow into the picture, taking up the task of describing the universe without reference to such time or space - abstractions for which our language lacks adequate terms. ↗