You can put in all the difficulties, jumps, runs, and any other devilish complexities you like, except octave spans and similar features which do not suit the formation of hands. ↗
On 'Honeybabysweetiedoll' I used a Whammy, a Boss OC-3 octave box, a Sustainer and a Line 6 DL4 Delay Modeler. That's only on the intro, where all those weird noises are happening. ↗