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This is largely the methodology I've used throughout my career - that is, starting with a question as to what might be the properties of a set of compounds that could be invented which were unusual and unpredictable. Many times I've felt a bit like Columbus setting sail. ↗
I hadn't learned to read by third grade, which wasn't unusual for some kids. I knew something was wrong because I couldn't see or understand the words the way the other kids did. I wasn't the least bit bothered - until I was sent back to the second-grade classroom for reading help after school. ↗
I've got some great guy friends. They can start out as crushes. But when you realize something isn't going to happen, you make a choice whether or not the friendship is worth it. And it usually is. Then you can laugh about the fact that you used to have a crush on him or he had one on you. ↗