I remember my brother Nash had just directed me in 'The Square,' and I was sitting in Australia going: 'No one's called me about working for ages. I don't know if I'm ever going to get another job.'

Edgerton attended the Nepean Drama School at the University of Western Sydney before moving on to various stage productions most notably at Sydney Theatre Company – Blackrock Third World Blues and Love for Love – and Bell Shakespeare – Henry V – as well as television series. On 7 February 2010 he was cast in Matthijs van Heijningen Jr. In 2012 Edgerton visited Nepal where he saw sight restored first hand.

He is best known for his roles in 2000s and 2010s films like Star Wars Episode II: Attack of the Clones (2002) Star Wars Episode III: Revenge of the Sith (2005) Animal Kingdom (2010) The Thing (2011) Warrior (2011) The Odd Life of Timothy Green (2012) and Zero Dark Thirty (2012).