A lot of people asked me if it was frustrating not having a clear specific diagnosis, but I didn't mind, I just chose the most optimistic diagnosis.

Personal life
Duffy was leading a relatively carefree youth in the heyday of her modeling career when in 1995 Karen Duffy was diagnosed with the relatively rare disease sarcoidosis. In 2006 Duffy hosted House of Tiny Terrors on TLC. Karen Duffy.