Whenever somebody says they need an angle for their story I always fear that they've got an idea and they want me to fit into it or they want me to come up with an idea myself or I'm supposed to be more revealing than I've been, and to me it just sounds like something I don't want to do.

In the final episode of the series he performed a parody of Sharon Stone's 'flashing' scene from Basic Instinct and a parody of "Dr. He had a recurring role as a transvestite DEA agent on the series Twin Peaks and played the narrator/host in the long-running Showtime erotica/softcore TV series Red Shoe Diaries. In 2000 he starred in the feature film Return to Me a romantic comedy/drama directed by Bonnie Hunt and co-starring Minnie Driver and Carroll O'Connor.

He is best known for playing Fox Mulder on The X-Files and Hank Moody on Californication both of which have earned him Golden Globe awards.