Chemistry is really about two people who like to act together, I think. It's like tennis in the most cliched way. It's like if you hit the ball, they hit the ball back, and they don't hit it into the stands, and they don't put the ball in their pocket and walk off - and they don't argue with the umpire, you know?

In the final episode of the series he performed a parody of Sharon Stone's 'flashing' scene from Basic Instinct and a parody of "Dr. He had a recurring role as a transvestite DEA agent on the series Twin Peaks and played the narrator/host in the long-running Showtime erotica/softcore TV series Red Shoe Diaries. In 2000 he starred in the feature film Return to Me a romantic comedy/drama directed by Bonnie Hunt and co-starring Minnie Driver and Carroll O'Connor.

He is best known for playing Fox Mulder on The X-Files and Hank Moody on Californication both of which have earned him Golden Globe awards.