Television is more of a business. You can't take as many risks, because there's so many channels now, and the advertising's dropping.

Since the mid-1990s Delany has served on the board of the Scleroderma Research Foundation. Delany is currently filming the crime drama Freelancers with director Jessy Terrero. New York Daily News TV critic David Bianculli gave a positive review to both her performance as an actor -- "Delany as always does pensive and independent better than most actresses"—and as a producer.

In 2000s Dana Delany returned to television with a string of short-lived television series beginning with Pasadena (2001) Presidio Med (2002–2003) and Kidnapped (2006–2007). She received further recognition for her performances in the films Light Sleeper (1992) Tombstone (1993) Exit to Eden (1994) The Margaret Sanger Story (1995) Fly Away Home (1996) True Women (1997) and Wide Awake (1998). Since the mid-1990s Delany has served on the board of the Scleroderma Research Foundation.