Namely, we have no right to believe a thing true because everybody says so unless there are good grounds for believing that some one person at least has the means of knowing what is true, and is speaking the truth so far as he knows it.

He was the first to suggest that gravitation might be a manifestation of an underlying geometry. He was much interested too in universal algebra and elliptic functions his papers "Preliminary Sketch of Biquaternions" (1873) and "On the Canonical Form and Dissection of a Riemann's Surface" (1877) ranking as classics. This paper was famously attacked by pragmatist philosopher William James in his "Will to Believe" lecture.

In his philosophical writings he coined the expression "mind-stuff". Building on the work of Hermann Grassmann he introduced what is now termed geometric algebra a special case of the Clifford algebra named in his honour with interesting applications in contemporary mathematical physics and geometry.