We cannot suppose therefore that God has made an order of beings, with such mental qualities and powers, for the sole purpose of being used as beasts, or instruments of labour.

The Clarkson School Wisbech is named after him as is Thomas Clarkson Academy. The "box" of his collection became an important part his public meetings and was an early example of a visual aid. For Rees's Cyclopaedia he contributed the article on the Slave Trade Vol 33 1816.

In 1840 he was the key speaker at the Anti-Slavery Society (today known as Anti-Slavery International) conference in London which campaigned to end slavery in other countries. In his later years Clarkson campaigned for the abolition of slavery worldwide. He helped found The Society for Effecting the Abolition of the Slave Trade and helped achieve passage of the Slave Trade Act of 1807 which ended British trade in slaves.