Being an actor is mostly about rejection and being out of work. It was a fast lesson in all of that stuff.

You're a freelancer. Along with Glenn Close Rose Byrne appeared in all of the show's fifty-nine episodes. In 2006 Byrne portrayed Gabrielle de Polastron duchesse de Polignac a French aristocrat and friend of Marie Antoinette in Sofia Coppola's Marie Antoinette with Kirsten Dunst and appeared in The Dead Girl directed by Karen Moncrieff.

In 2000 Rose Byrne played a leading role in the Australian film The Goddess of 1967 which brought her a Venice Film Festival award for Best Actress. Byrne made her screen debut in 1994 with a small role in the film Dallas Doll.