I loved performing; I was always trying to impress my siblings by being a clown. I think that came from being the runt of the litter.

You're a freelancer. Along with Glenn Close Rose Byrne appeared in all of the show's fifty-nine episodes. In 2006 Byrne portrayed Gabrielle de Polastron duchesse de Polignac a French aristocrat and friend of Marie Antoinette in Sofia Coppola's Marie Antoinette with Kirsten Dunst and appeared in The Dead Girl directed by Karen Moncrieff.

In 2000 Rose Byrne played a leading role in the Australian film The Goddess of 1967 which brought her a Venice Film Festival award for Best Actress. Byrne made her screen debut in 1994 with a small role in the film Dallas Doll.