Moralism and ignorance are responsible for the constant stereotyping of prostitutes by their lowest common denominator -- the sick, strung-out addicts, couched on city stoops, who turn tricks for drug money. . . . The most successful prostitutes in history have been invisible. That invisibility was produced by their high intelligence, which gives them the power to perceive, and move freely but undetected in the social frame. The prostitute is a superb analyst, not only in evading the law but in initiating the unique constellation of convention and fantasy that produces a stranger’s orgasm. She lives by her wits as much as her body. She is a psychologist, actor, and dancer, a performance artist of hyper-developed sexual imagination.

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For over a decade Paglia was the partner of artist Alison Maddex. Clive James noted that Paglia tends to focus on American works as it moves from Shakespeare forward through time with Yeats following Coleridge as the last European discussed but emphasized her range of sympathy and her ability to juxtapose and unite distinct art forms in her analysis.

She is known as a critic of American feminism and is also strongly critical of the influence of French writers such as Jacques Lacan Jacques Derrida and Michel Foucault. Paglia has celebrated Madonna and taken radical libertarian positions on controversial social issues such as abortion homosexuality and drug use. She wrote Sexual Personae: Art and Decadence from Nefertiti to Emily Dickinson (1990) a best-selling work of literary criticism among other books and essays.