It is difficult to feel sympathy for these people. It is difficult to regard some bawdy drunk and see them as sick and powerless. It is difficult to suffer the selfishness of a drug addict who will lie to you and steal from you and forgive them and offer them help. Can there be any other disease that renders its victims so unappealing? Would Great Ormond Street be so attractive a cause if its beds were riddled with obnoxious little criminals that had “brought it on themselves?

Of his time presenting the show he said "The three years I've spent on Big Brother's Big Mouth have been an unprecedented joy". He starred in the 2011 remake of the 1981 Dudley Moore film Arthur. He presented Dancefloor Chart touring nightclubs in Britain and Ibiza and hosted the tea-time request show Select.

He married American pop singer Katy Perry in October 2010; they separated in December 2011 and were divorced the following year. In 2007 he had his first major film role in St Trinian's. In 2004 Brand achieved mainstream fame in the UK as the host of Big Brother's Big Mouth a Big Brother spin-off.