My dear Watson, you as a medical man are continually gaining light as to the tendencies of a child by the study of the parents. Don't you see that the converse is equally valid. I have frequently gained my first real insight into the character of parents by studying their children.” —Sherlock Holmes, “The Adventure of the Copper Beeches

He had maintained a platonic relationship with Jean while his first wife was still alive out of loyalty to her. A sequel to A Study in Scarlet was commissioned and The Sign of the Four appeared in Lippincott's Magazine in February 1890 under agreement with the Ward Lock company. Conan Doyle fathered five children.

He was a prolific writer whose other works include fantasy and science fiction stories plays romances poetry non-fiction and historical novels.