What was so painful about Amy’s death is that I know that there is something I could have done. I could have passed on to her the solution that was freely given to me. Don’t pick up a drink or drug, one day at a time. It sounds so simple; it actually is simple but it isn’t easy; it requires incredible support and fastidious structuring.

Of his time presenting the show he said "The three years I've spent on Big Brother's Big Mouth have been an unprecedented joy". He starred in the 2011 remake of the 1981 Dudley Moore film Arthur. He presented Dancefloor Chart touring nightclubs in Britain and Ibiza and hosted the tea-time request show Select.

He married American pop singer Katy Perry in October 2010; they separated in December 2011 and were divorced the following year. In 2007 he had his first major film role in St Trinian's. In 2004 Brand achieved mainstream fame in the UK as the host of Big Brother's Big Mouth a Big Brother spin-off.