I started as a news photographer at the University Of Texas' Daily Texan.

The strip eventually appeared in over 1200 newspapers around the world until Berkeley retired the daily strip in 1989 stating that he wanted to terminate the strip while it was still popular. Breathed has been a supporter of the animal rights group PETA and illustrated the cover of their Compassionate Cookbook T-shirts and other merchandise. Breathed plans to focus on writing children's books.

Bloom County earned Breathed the Pulitzer Prize for editorial cartooning in 1987. Guy Berkeley "Berke" Breathed (/ˈbrɛðɨd/ BRETH-əd; born June 21 1957) is an American cartoonist children's book author/illustrator director and screenwriter best known for Bloom County a 1980s cartoon-comic strip that dealt with sociopolitical issues as understood by fanciful characters (e.