I think I was born because my parents had two boys and wanted to give it one more go and try for a girl... they got me instead.

Borstein gave birth to their daughter Henrietta Borstein Douglas on October 1 2012. She has made at least three guest appearances once as Lois Griffin on the Comedy Central animated program Drawn Together. Douglas proposed to her during the taping of a MADtv skit; the couple married in 1999.

She was trained in improvisational comedy at the ACME Comedy Theatre near Hollywood California and was selected to join MADtv after being scouted by talent agents who noticed her work at the theatre. A native of Deerfield Illinois Borstein is a graduate of San Francisco State University where Alex Borstein studied rhetoric. She is well known for her long-running role as Lois Griffin on the animated television series Family Guy and as a cast member on the sketch comedy series MADtv.