I'm always the last person they go to with a sequel, because I'm the most skeptical. You know, I'm very proud of what we've done, and I don't want to screw up our series.

The same year Sigourney Weaver appeared opposite Harrison Ford in a supporting role as Katharine Parker in the film Working Girl. By the early 1990s Weaver appeared in several films including Ang Lee's The Ice Storm earning her another Golden Globe nomination for Best Supporting Actress and winning a BAFTA Award followed by Dave opposite Kevin Kline and Frank Langella. In May 2010 there were reports that Weaver had been cast for the lead role Margaret Matheson in the Spanish thriller film Red Lights.

Other notable roles include Dana Barrett in Ghostbusters and its sequel Ghostbusters II Gorillas in the Mist: The Story of Dian Fossey Working Girl The Ice Storm Galaxy Quest Prayers for Bobby and Grace Augustine in Avatar. She played the lead role on USA Network's Political Animals miniseries as Elaine Barrish a divorced former First Lady and Governor of Illinois as well as the current Secretary of State. She was also nominated for a Drama Desk Award and a Tony Award.