Sometimes you trust someone who turns out not to be honest. There are a lot of things that happen in life that don't turn out the way you're given the impression that they will. And I think that's all kind of a con. But I think we've probably all been hurt.

The same year Sigourney Weaver appeared opposite Harrison Ford in a supporting role as Katharine Parker in the film Working Girl. By the early 1990s Weaver appeared in several films including Ang Lee's The Ice Storm earning her another Golden Globe nomination for Best Supporting Actress and winning a BAFTA Award followed by Dave opposite Kevin Kline and Frank Langella. In May 2010 there were reports that Weaver had been cast for the lead role Margaret Matheson in the Spanish thriller film Red Lights.

Other notable roles include Dana Barrett in Ghostbusters and its sequel Ghostbusters II Gorillas in the Mist: The Story of Dian Fossey Working Girl The Ice Storm Galaxy Quest Prayers for Bobby and Grace Augustine in Avatar. She played the lead role on USA Network's Political Animals miniseries as Elaine Barrish a divorced former First Lady and Governor of Illinois as well as the current Secretary of State. She was also nominated for a Drama Desk Award and a Tony Award.