What I am trying to get across to you; is please take of yourselves and those that you love; because that is what we are hear for, that's all we got, and that is all we can take with us. Are you with me?

Martell Foundation's work in leukemia and cancer research. In September 1970 Vaughan was temporarily recruited into Cast of Thousands a band that included future actor Stephen Tobolowsky. Vaughan was also photographed playing a National Duolian Epiphone Riviera Gibson Flying V as well as several other models.

After successful touring the group released the albums Couldn't Stand the Weather (1984) and Soul to Soul (1985) the latter of which featured new keyboardist Reese Wynans. In June 1989 In Step was released and earned them a Grammy Award for Best Contemporary Blues Performance. He was influenced by blues musicians including Albert King Freddie King Otis Rush and Muddy Waters and rock guitarists such as Jimi Hendrix and Lonnie Mack.