No one in my family was a reader of literary fiction. So, I didn't have encouragement, but I didn't have discouragement, because I don't think anybody knew what that meant.

Tan is also in a band with several other well-known writers the Rock Bottom Remainders. When Tan was 15 years old her older brother Peter and father both died of brain tumors within a year of each other. She is the second of three children born to Chinese immigrants Daisy (née Li) who was forced to leave her three daughters from a previous marriage behind in Shanghai and John Tan an electrical engineer and Baptist minister.

In addition to these Tan has written two children's books: The Moon Lady (1992) and Sagwa the Chinese Siamese Cat (1994) which was turned into an animated series which aired on PBS. Tan is also in a band with several other well-known writers the Rock Bottom Remainders. Her most recent novel Saving Fish from Drowning explores the tribulations experienced by a group of people who disappear while on an expedition in the jungles of Burma.