I remember when I first started in the business, I lost a lot of friends. Some were jealous, some were annoyed at the fact that I was an actress.

In the same year Tamblyn had a recurring role alongside her father in the IFC sitcom The Increasingly Poor Decisions of Todd Margaret. Tamblyn and comedian and actor David Cross were rumored to have been dating as early as April 2008. In 2008 Amber Tamblyn was featured in the Write Bloody Publishing anthology The Last American Valentine: Illustrated poems to seduce and destroy.

Her feature film work includes roles in The Sisterhood of the Traveling Pants The Grudge 2 The Ring and 127 Hours; Amber Tamblyn recently had an extended arc as Martha M. D. Masters on the main cast of the medical drama House M.