I remember being at Greenblatt's on Sunset, and some guy just walked straight up to me, and he had some bling on and whatever, and said something about a party down in Malibu and asked if I would jump in his car and go to the party. All I could think was, 'Who are you? I don't know you, and I don't care about how good your car is.'

In November 2011 Yvonne Strahovski was cast as the female lead in I Frankenstein. Strahovski appeared in the 2011 film Killer Elite alongside Jason Statham Clive Owen and Robert De Niro. Although Yvonne Strahovski portrays an American in the series Yvonne Strahovski briefly spoke in a "Hollywood" Australian accent in the episode "Chuck Versus the Ex".

She is featured in season 7 of the Showtime series Dexter as Hannah McKay. After graduating from the University of Western Sydney Yvonne Strahovski featured in a number of Australian television shows. She then starred as CIA Agent Sarah Walker in the American television series Chuck a role for which Yvonne Strahovski is widely known.