I didn't think that a career in theater was very realistic so I thought the only thing I could make money doing and still be somewhat artistic was, god help me, advertising.

Schreiber reprised his role as narrator for HBO's 24/7: Road to the Winter Classic NHL documentary which followed the Pittsburgh Penguins and Washington Capitals as they prepared to face each other in the 2011 NHL Winter Classic at Heinz Field in Pittsburgh Pennsylvania on January 1 2011. "
In 2002 he starred in Neil LaBute's play The Mercy Seat along with Sigourney Weaver on Off-Broadway that was critically and commercially very successful.

He became known during the late 1990s and early 2000s having initially appeared in several independent films and later mainstream Hollywood films including the Scream trilogy of horror films Phantoms The Sum of All Fears X-Men Origins: Wolverine Salt and Goon. Schreiber is also a respected stage actor having performed in several Broadway productions. Isaac Liev Schreiber (pron.