I had had some months of depression. Not serious enough to keep me from work. So, I guess you'd call that a mild depression. It was becoming worse. And I was being treated for it with anti-depressants.

She subsequently earned a scholarship to Indiana University where Jane Pauley was involved in the Kappa Kappa Gamma sorority. After leaving The Today Show Pauley hosted Real Life with Jane Pauley and served as deputy anchor for NBC Nightly News. In 2009 Pauley joined the Board of Directors of The Mind Trust an Indianapolis-based non-profit organization that supports education innovation and reform.

She is best known for her 13-year tenure on NBC's Today program followed by 12 years as co-host of Dateline NBC and for her public acknowledgements of her struggle with bipolar disorder.