I took a bottle of pills. I'd been in Europe and I had a lot of absinthe and I was just drinking and drinking, trying to, you know, just shut my body down.

Osbourne lost 23 kg in Thailand at a Muay Thai martial arts camp in Pattaya in order to be fit enough to climb El Capitan (which he achieved) whilst filming the first series of Jack Osbourne: Adrenaline Junkie. Osbourne has since pursued a career as a fitness and travel reporter presenting shows such as Jack Osbourne: Adrenaline Junkie (2005-09) and BBC's Saving Planet Earth (2007). Adrenaline Junkie focuses on Osbourne's training for sports like rock climbing mountaineering and a jungle trek in Belize from the Chiquibul Chamber through dense jungle ending at Caracol ruins (Guided by the UK extreme conservation organisation Trekforce).

He is best known as a star of MTV's reality series The Osbournes (2003-05) along with his father Ozzy mother Sharon and sister Kelly. He was diagnosed with relapsing remitting multiple sclerosis in 2012.