I don't want this big stardom thing. I just want a good script.

Later on in 1982 Annette O'Toole appeared briefly as Nick Nolte's girlfriend in 48 Hours. On July 7 2007 O'Toole appeared as a backing singer for her husband's fictional band Spinal Tap at the London leg of the Live Earth concerts. On January 19 2010 it was announced that O'Toole would be returning to Smallville for at least one episode.

She is most recently known for portraying Martha Kent the mother of Clark Kent on the television series Smallville.