One of the concepts essential to molecular manufacturing is that of a self-replicating manufacturing system. That concept has lagged behind in its acceptance.

1998 Feynman Prize in Nanotechnology for computational modeling of molecular tools for atomically-precise chemical reactions
1999 IEEE Koji Kobayashi Computers and Communications Award
2000 RSA award for the invention of public key cryptography. Career
Merkle was the manager of compiler development at Elxsi from 1980. Hamming Medal in 2010.

Ralph C. Merkle appears in the science fiction novel The Diamond Age involving nanotechnology.