Selling millions of albums is a sign you've infiltrated the culture.

In 2006 Manson planned to record a John Lennon cover version for the Amnesty International Instant Karma charity compilation with bassist Eric Avery however a scheduling misunderstanding left them short of time and unable to record the song. Funds raised for the Pablove Foundation directly supports the pediatric cancer community in and around Children's Hospital Los Angeles. There’s a little of each of them in her voice" also stating "In the course of each song Shirley Manson let her voice rise in anger contempt or passion".

For much of her international career Manson commuted between her home city of Edinburgh to the United States to record with Garbage; Shirley Manson now lives and works in Los Angeles. 0 and a greatest hits album. The resulting self-titled debut Garbage was a worldwide hit and was followed by three studio albums including the multiple Grammy Award-nominated Version 2.