The first night was awful because I was so afraid, and I was never more afraid because it was going out of my character to be outgoing and to be vulnerable and to be out there and onstage. My hands were sweaty and I couldn't swallow, and I drank a bottle of wine to calm my nerves.

Lopez was a cast member and commentator for HBO’s hit sports show Inside the NFL for the 2003–2004 football season. Kirstie responded on Twitter "Don't worry about George's comments…just remember what happens to the big bad drunk woolf…falls in a boiling pot of vodka. He also claimed he had a physical altercation with Mencía over the alleged appropriation.

His stand-up comedy examines race and ethnic relations including Mexican American culture. He is mostly known for starring in his self-produced ABC sitcom George Lopez. He was the host of the late-night talk show Lopez Tonight on TBS until its cancellation on August 12 2011.