One of the things that's influenced me musically was my experience at Brown University. I was surrounded by musicians that I really admired, and felt challenged to come up with music, lyrics, and recordings that stood up to the expectations of those musicians and myself.

Loeb has made several guest appearances on television shows such as The Nanny in 1997 and Cupid the following year. Loeb also voiced the character of Lutina in the video game Grandia Xtreme and characters for The Rugrats Movie and Shorty McShorts' Shorts. Loeb and Nine Stories received a Grammy nomination for Best Pop Performance by a Group and were named Best International Newcomer in the Brit Awards.

She launched her career in 1994 with the song "Stay (I Missed You)" which was included in the film Reality Bites. Her first joint children's book and album Lisa Loeb's Silly Sing-Along: The Disappointing Pancake and Other Zany Songs was publiLisa Loebd in 2011.