The thing is, I want to play real characters and not all girls can be pretty. The thing is, you get these girls who say 'I'm a character actor' then you see them in a role and nothing has really changed but the outfit.

Lewis features on the track "Bad Brother" by the band The Infidels from The Crow: Salvation Soundtrack album which was released on April 2000. In October 2010 Juliette Lewis was the victim of a hit-and-run car accident in which an unknown driver T-boned the Lincoln Town Car in which Juliette Lewis was traveling. She played a rock singer in the film Strange Days doing her own singing on covers of two songs written by PJ Harvey revealing her musical ability.

She gained fame for her role in the 1991 thriller Cape Fear for which Juliette Lewis was nominated for both an Academy Award and Golden Globe for Best Supporting Actress. Lewis launched a career as a singer and musician leading the American rock band Juliette and the Licks until 2009. This followed with major roles in What's Eating Gilbert Grape Natural Born Killers The Evening Star Kalifornia From Dusk Till Dawn and The Other Sister.