Things change and work changes. Right now I like the idea of enveloping a space and getting messages across that connect to the world in ways that seem familiar but are different.

Kruger's early monochrome pre-digital works known as ‘paste ups’ reveal the influence of the artist’s experience as a magazine editorial designer during her early career. In September 2009 Kruger’s Between Being Born and Dying a major installation commissioned by the Lever House Art Collection opened at the New York City architectural landmark Lever House. Kruger juxtaposes her imagery and text containing criticism of sexism and the circulation of power within cultures is a recurring motif in Kruger's work.

The phrases in her works often include pronouns such as "you" "your" "I" "we" and "they". Much of her work consists of black-and-white photographs overlaid with declarative captions—in white-on-red Futura Bold Oblique or Helvetica Ultra Condensed.